Researchers:Apply here to submit research protocol.

OmegaPure Human Nutrition Research

Universities and other institutions across the country have conducted numerous studies to better understand the benefits of omega-3 fatty acids in human nutrition. This section contains a collection of published scientific studies that support the benefits of omega-3 fatty acids from fish oil in human health.

Please select your category of interest for a list of topics.

Brain and Nervous System

Brain Function
- Brain Development
  - - Nutrition in Brain Development and Aging: Role of Essential Fatty Acids
- IQ
  - - Why Fat is Essential for a Healthy Mind
    - Effect of long-chain polyunsaturated fatty acids in infant formula on problem solving at 10 months of age.
- Dyslexia
  - - Dark adaptation, motor skills, docosahexaenoic acid, and dyslexia
- Dementia
  - - Fatty acid analysis of blood plasma of patients with alzheimer's disease, other types of dementia, and cognitive impairment
- Alzheimer's
  - - Consumption of Fish and n-3 Fatty Acids & Risk of Incident Alzheimer Disease
- ADD/ADHD
  - - Effects of an open-label pilot study with high-dose EPA/DHA concentrates on plasma phospholipids and behavior in children with attention deficit hyperactivity disorder
- Depression and Suicide
  - - EPA but Not DHA Appears To Be Responsible for the Efficacy of Omega-3 Long Chain Polyunsaturated Fatty Acid Supplementation in Depression: Evidence from a Meta-Analysis of Randomized Controlled Trials
- Aggression
- Anxiety and Stress
  - - A Solid Dietary Fat Containing Fish Oil Redistributes Lipoprotein
- Vision
  - Retinopathy
  - Cataracts
  - Dry Eye Syndrome
  - Macular Degeneration
  - - Meta-Analysis of Dietary Essential FA & LCPUFA as they Relate to Visual Resolution Acuity in Healthy Preterm Infants

Neurological Disorders and Disease
- Bi-Polar Disorder
- Schizophrenia
- Autism
- Multiple Sclerosis
- Lou Gehrig's Disease
- Parkinson's Disease
- Stroke

Cardiovascular and Circulatory Systems

Atherosclerosis
- - Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men.
  - Intakes of long-chain omega-3 fatty acid associated with reduced risk for death from coronary heart disease in healthy adults
  - Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids
  - Dietary intervention with oil rich fish reduces platelet-monocyte aggregation in man.
  - Intake of Fish and n3 Fatty Acids and Risk of Coronary Heart Disease Among Japanese: The Japan Public Health Center-Based (JPHC) Study Cohort I.
  - Effect of different antilipidemic agents and diets on mortality
  - Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial.
  - n-3 Fatty acids and the prevention of coronary atherosclerosis
  - The effect of dietary omega-3 fatty acids on coronary atherosclerosis.

Protection and Anti-inflammatory

Triglycerides
- - Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women
  - Effects of four doses of n-3 fatty acids given to hyperlipidemic patients for six months

Cholesterol
- - Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men.

Angina
- - Effects of low-dose fish oil concentrate on angina, exercise tolerance time, serum triglycerides, and platelet function

Heart Attack
- - n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study
  - Association between n-3 fatty acid consumption and ventricular ectopy after myocardial infarction.
  - Blood concentrations of individual long-chain n–3 fatty acids and risk of nonfatal myocardial infarction1
  - Effects of fish-oil supplementation on myocardial fatty acids in humans.
  - The Fish in Secondary Prevention of Heart Disease (FISH) Survey—Primary Care Physicians and Omega-3 Fatty Acid Prescribing Practice.
  - N-3 fatty acids: priority for post-myocardial infarction clinical trials.
  - Efficacy of n-3 polyunsaturated fatty acids after myocardial infarction: results of GISSI-Prevenzione trial.
  - Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of GISSI-Prevenzione.
  - Fish consumption and risk of sudden cardiac death.
  - Use of fish oils appears to reduce infarct size as estimated from peak creatine kinase and lactate dehydrogenase activities.
  - Fish consumption, n-3 fatty acids in cell membranes, and heart rate variability in survivors of myocardial infarction with left ventricular dysfunction.
  - Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest.

Heart Rate and Arrhythmias
- - Antiarrhythmic effects of omega-3 fatty acids: from epidemiology to bedside.
  - Heart rate variability and fatty acid content of blood cell membranes: a dose-response study with n-3 fatty acids.

Stroke
- - Intake of fish and omega-3 fatty acids and risk of stroke in women

Blood Pressure and Hypertension

Heart Transplantation
- - Hypertension prophylaxis with omega-3 fatty acids in heart transplant recipients

Heart Diseases
- Cardiovascular Disease
  - - Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids.
    - Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    - New evidence in support of the cardiovascular benefit of long-chain n-3 fatty acids
- Coronary Heart Disease
  - - n-3 Long-chain polyunsaturated fatty acids reduce risk of coronary heart disease death: extending the evidence to the elderly1
    - C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease
    - n-3 fatty acids in adipose tissue and coronary artery disease are inversely related
    - Blood omega-3 and trans fatty acids in middle-aged acute coronary syndrome patients.
    - Fish and long-chain omega-3 fatty acid intake and risk of coronary heart disease and total mortality in diabetic women.
    - Fish and omega-3 fatty acid intake and risk of coronary heart disease in women.
    - Fish oil-derived fatty acids, docosahexaenoic acid and docosapentaenoic acid, and the risk of acute coronary events.
    - Serum fatty acids and the risk of coronary heart disease.

Respiratory System

Asthma
- - Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma

Emphysema

Cystic Fibrosis

ARDS

Chronic Lung Disease

Smokers

Skeletal System

Tooth Loss

Rheumatoid Arthritis

Bone Density

Bone Development
- - Omega-3 Polyunsaturated Fatty Acids and Skeletal Health
  - Modulatory effect of omega-3 polyunsaturated fatty acids on osteoblast function and bone metabolism

Joint Health
- - Beating Arthritis with the Right Food Choices

Dermatological System

Acne

Eczema

Psoriasis

Muscular System

Fibromyalgia

Digestive System

Ulcers

Inflammatory Bowel Disease

Chron's Disease
- - Fish oil and antioxidants alter the composition and function of circulating mononuclear cells in Crohn disease

Intestinal Disorders

Immune System

AIDS

Lupus

Other Autoimmune Diseases
- - Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases

Reproductive System

Male Reproductive System
- Prostate Health

Female Reproductive System
- Breastfeeding
- Formula
  - - Marine oils in infant formulae
- Infant Development
- Pregnancy
- Menopause
- HPV
- Premenstrual Syndrome